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Publications for WUSTL, TAMU, UCB, UCSB, UTSW


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Manuscripts

  1. Yongjian Liu, Richard Pierce, Hannah Luehmann, Terry Sharp, Michael Welch. Positron Emission Tomography Imaging of Chemokine Receptors in Vascular Injury Accelerated Atherosclerosis. Journal of Nuclear Medicine, In Press.

  2. Yunjun Guo, Tolulope Aweda, Kvar Black, Yongjian Liu. Development of Radiolabeled Nanoparticles for Theranostic Applications. Special Issue on “Imaging Agents in Medicinal Chemistry and Drug Discovery in Current Topics in Medicinal Chemistry, In Press

  3. Gustafson, TP, Dergunov, SA, Akers, WJ, Chen Q., Magalotti, S., Achilefu, S., Pinkhassik, E., Berezin, MY, Blood Triggered Rapid Release Porous Nanocapsules. RCS Advances 2013, DOI:10.1039/C3RA22693J. 

  4. Magalotti, S., Gustafson, TP., Cao Q., Abendschein D., Pierce, R., Berezin, MY, Akers WJ. Evaluation of Inflammatory Response to Acute Ischemia Using Near-Infrared Fluorescent Reactive Oxygen Sensors. Mol Imaging Biol,  2013 4 DOI: 10.1007/s11307-013-0614-2.

  5. Pressly, E. D.; Pierce, R. A.; Connal, L. A.; Hawker, C. J.; Liu, Y. Nanoparticle PET/CT imaging of natriuretic peptide clearance receptor in prostate cancer. Bioconjugate Chem. 2013, 24:196-204. 

  6. Li, A.; Luehmann, H. P.; Sun, G.; Samarajeewa, S.; Zou, J.; Zhang, S.; Zhang, F.; Welch, M. J.; Liu, Y.; Wooley, K. L. Synthesis and in vivo Pharmacokinetic Evaluation of Degradable Shell Crosslinked Polymer Nanoparticles with Poly(carboxybetaine) vs. Poly(ethylene glycol) Surface-grafted Coatings, ACS Nano, 2012, 6(10), 8970-8982, NIHMSID #41368.

  7. Shrestha, R.; Elsabahy, M.; Florez-Malaver, S.; Samarajeewa, S.; Wooley, K. L. Endosomal Escape and Efficient siRNA Delivery by Optimization of Cationic Shell Crosslinked Knedel-like Nanoparticles with Tunable Buffering Capacities, Biomaterials, 2012, 33(33), 8557-8568 NIHMSID #398995

  8. Lundberg, P.; Lynd, N. A.; Zhang, Y.; Zeng, X.; Krogstad, D. V.; Paffen, T.; Malkoch, M.; Nyström, A. M.; Hawker, C. J. pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers. Soft Matter 2012, 9, 82–89.

  9. Albertazzi, L.; Mickler, F. M.; Pavan, G. M.; Salomone, F.; Bardi, G.; Panniello, M.; Amir, E.; Kang, T.; Killops, K. L.; Bräuchle, C.; Amir, R. J.; Hawker,     C. J. Enhanced bioactivity of internally functionalized cationic dendrimers with PEG cores. Biomacromolecules 2012, 13, 4089–4097.

  10. Connal, L. A.; Lynd, N. A.; Robb, M. J.; See, K. A.; Jang, S. G.; Spruell, J. M.; Hawker, C. J. Mesostructured block copolymer nanoparticles: Versatile templates for hybrid inorganic/organic nanostructures. Chem. Mater. 2012, 24, 4036–4042.

  11. Lundberg, P.; Lee, B. F.; van den Berg, S. A.; Pressly, E. D.; Lee, A.; Hawker, C. J.; Lynd, N. A. Poly[(ethylene oxide)-co-(methylene ethylene oxide)]: A hydrolytically degradable poly(ethylene oxide) platform. ACS Macro Letters 2012, 1, 1240–1243.

  12. Ornelas-Megiatto C, Shah PN, Wich PR, Cohen J, Tagaev JA, Smolen JA, Wright BD, Youngs WJ, Fréchet JMJ, Cannon CL. Aerosolized Antimicrobial Agents Based on Degradable Dextran Nanoparticles Loaded with Silver Carbene Complexes. Mol. Pharmaceutics, 2012, 9(11):3012-3022.

  13. Gustafson, TP., Cao Q., Achilefu, S., Berezin, MY. Defining a Polymethine Dye for Fluorescence Anisotropy Applications in the NIR Spectral Range, ChemPhysChem, 2012, (3):716-23.

  14. Zhenghui Wang, Ke Zhang, Yuefei Shen, Jillian Smith, Sharon Bloch, Samuel Achilefu, Karen L. Wooley, John-Stephen Taylor*  “Imaging mRNA expression levels in living cells with PNA∙DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles”.  Org. Biomol. Chem.2012, submitted.

  15. Yuefei Shen, Huafeng Fang, Ke Zhang, Ritu Shrestha, Karen L.Wooley, and John-Stephen A. Taylor, “Efficient protection and transfection of siRNA by cationic shell-crosslinked knedel-like nanoparticles (cSCKs)”.  J. Nucleic Acid Therapeutics  in press.

  16. ZhenghuiWang, Ke Zhang, Karen L.Wooley, and John-Stephen Taylor*, “Imaging mRNA Expression in Live Cells via PNA·DNA Strand Displacement-Activated Probes”, J. Nucl. Acids 2012 2012:962652. doi: 10.1155/2012/962652.

  17. Shrestha R, Shen Y, Pollack KA, Taylor JS, Wooley* KL. “Dual peptide nucleic acid- and peptide-functionalized shell cross-linked nanoparticles designed to target mRNA toward the diagnosis and treatment of acute lung injury”.  2012 Bioconjug Chem. 2012 574-85. 

  18. Cauët, S. I.; Lee, N. S.; Lin, L. Y.; Wooley, K. L., "Individual Nano-Objects Obtained via Hierarchical Assembly of Polymer Building Blocks". In: Matyjaszewski K and Möller M (eds.) Polymer Science: A Comprehensive Reference, Vol 6, pp. 775–820. 2012 Amsterdam: Elsevier BV.
  19. Zou, J.; Zhang, S.; Shrestha, R.; Seetho, K.; Donley, C. L.; Wooley, K. L. “pH-Triggered reversible morphological inversion of orthogonally-addressable poly(3-acrylamidophenylboronic acid)-block-poly(acrylamidoethylamine) micelles and their shell crosslinked nanoparticles”, Polym. Chem., 2012, DOI: 10.1039/C2PY20324C, NIHMS391196.
  20. Zeng, D.; Lee, N. S.; Liu, Y.; Zhou, D.; Dence, C.; Wooley, K. L.; Katzenellenbogen, J. A.; Welch, M. J. “64Cu Core-labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry”, ACS Nano, 2012 Jun 26;6(6):5209-19. Epub 2012 May 8.
  21. Amir, E.; Antoni, P.; Campos, L.M.; Damiron, D.; Gupta, N.; Amir, R.J.; Pesika, N.; Drockenmuller, E.; Hawker, C.J. "Biodegradable, multi-layered coatings for controlled release of small molecules", Chem. Commun., 2012 May 18; 48(40):4833-5. Epub 2012 Apr 12.
  22. Elsabahy, M.; Wooley, K. L. “Strategies toward Well-Defined Polymer Nanoparticles Inspired by Nature: Chemistry versus Versatility”, J. Polym. Sci., Part A: Polym. Chem, 2012, May 15; 50,1869-1880.
  23. Ibricevic, A; Gunsten, S.P.; Shrestha, R.; Sun, J.Y.; Taylor, J.-S.A.; Wooley, K.L.; Brody, S.L. “Cationic Charged Polymer-Based Nanoparticles As Vehicles For In Vivo siRNA Delivery To Alveolar Macrophages In A Lung Inflammation Model”, Am. J. Respir. Crit. Care Med. 2012; 185: A2140
  24. Lee, B.F.; Wolffs, M.; Delaney, K.T.; Sprafke, J.K.; Leibfarth, F.A.; Hawker, C.J.; Lynd, N.A. “Reactivity Ratios and Mechanistic Insight for Anionic Ring-Opening Copolymerization of Epoxides”, Macromolecules, 2012, 45, 3722-3731.
  25. Robb, M.J.; Connal, L.A.; Lee, B.F.; Lynd, N.A.; Hawker, C.J. "Functional block copolymer nanoparticles: toward the next generation of delivery vehicles", Polym. Chem., 2012, 3, 1618-1628.
  26. Zhang, X.; Bloch, S.; Akers, W.; Achilefu, S. “Near-infrared molecular probes for in vivo imaging”, Curr Protoc Cytom 2012, Apr; 12, 12.27.
  27. Tang, R.; Lee, H.; Achilefu, S. “Induction of pH sensitivity on the fluorescence lifetime of quantum dots by NIR fluorescent dyes”, J. Am. Chem. Soc. 2012 Mar 14;134(10):4545-8. Epub 2012 Feb 28.
  28. Shrestha, R; Shen, Y; Pollack, KA; Taylor, J-SA; Wooley, KL; "Dual Peptide Nucleic Acid- and Peptide-Functionalized Shell Cross-Linked Nanoparticles Designed to Target mRNA toward the Diagnosis and Treatment of Acute Lung Injury", Bioconjug Chem. 2012, Feb 28 [Epub ahead of print] DOI:10.1021/bc200629f
  29. Elsabahy, M; Wooley, K "Design of polymeric nanoparticles for biomedical delivery applications", Chem. Soc. Rev. 2012, Mar 12; 41(7):2545-61. Epub 2012 Feb 14
  30. Liu, Y; Welch, MJ; "Nanoparticles Labeled with Positron Emitting Nuclides: Advantages, Methods, and Applications", Bioconjug Chem. 2012, Feb 6 [Epub ahead of print] PMID:22242601
  31. Zhang, S; Li, A; Zou, J; Lin, LY; Wooley, KL; "Facile Synthesis of Clickable, Water-Soluble, and Degradable Polyphosphoesters",ACS Macro Lett., 2012, Feb 3, 1:328–333; DOI:10.1021/mz200226m
  32. Gustafson, TP; Cao, Q; Achilefu, S; Berezin, MY "Defining a Polymethine Dye for Fluorescence Anisotropy Applications in the Near-Infrared Spectral Range", ChemPhysChem 2012, Feb 2 online, DOI: 10.1002/CPHC.201100916
  33. Gustafson, TP; Yan, Y; Newton, P; Hunter, DA; Achilefu, S; Akers, WJ; Mackinnon, SE; Johnson, PJ; Berezin, MY "A NIR Dye for Development of Peripheral Nerve Targeted Probes", MedChemComm 2012, Jan 30 online, DOI:10.1039/C2MD00297C
  34. Guo, K., Achilefu, S., Berezin, MY. "Dating Bloodstains with Fluorescence Lifetime Measurements", Chemistry, Eur. J., 2012 Jan 27; DOI: 10.1002/chem.201102935, Featured in Chemistry World and Education in Chemistry magazines.
  35. Ornelas-Megiatto, C.; Wich, P.R.; Fréchet, J.M.J. "Polyphosphonium Polymers for siRNA Delivery: An Efficient and Non-Toxic Alternative to Polyammonium Carriers", J. Am. Chem. Soc. 2012, 4, 1902–1905. Epub Jan 19.
  36. Samarajeewa, S; Shrestha, R; Li, Y; Wooley, K "Degradability of Poly(Lactic Acid)-Containing Nanoparticles: Enzymatic Access through a Cross-Linked Shell Barrier", J. Am. Chem. Soc. 2011, Dec 13; DOI: 10.1021/ja2095602
  37. Liu, Y.; Pressly, E.D.; Abendschein, D.R.; Hawker, C.J.; Woodard, G.E.; Woodard, P.K.; Welch, M.J.  "Targeting angiogenesis using a C-type atrial natriuretic factor-conjugated nanoprobe and PET", J Nucl Med. 2011 Dec;52(12):1956-63. Epub 2011 Nov 2.
  38. Wich, P.R.; Fréchet, J.M.J. “Degradable Dextran Particles for Gene Delivery Applications” Aust. J. Chem. 2011 Nov. 29, 1, 15-19.
  39. Nyström, A. M.; Wooley, K. L. “The Importance of Chemistry in Creating Well-defined Nanoscopic Embedded Therapeutics:  Devices capable of the dual functions of imaging and therapy”, Acc. Chem. Res., 2011 Oct. 18; 44(10), 969-978, NIHMSID: 304595, PMCID: PMC3196832.
  40. Lee, Bongjae F.; Kade, Matthew J.; Chute, Jerred A.; Gupta, Nalini; Campos, Luis M.; Fredrickson, Glenn H.; Kramer, Edward J.; Lynd, Nathaniel A.; Hawker, Craig J., “Poly(allyl Glycidyl Ether)-A Versatile and Functional Polyether Platform”, J. Polym. Sci., Polym. Chem.; 2011 Oct 15; 49(20):4498-4504.
  41. Lin, Brian F.; Marullo, Rachel S.; Robb, Maxwell J.; Krogstad, Daniel V.; Antoni, Per; Hawker, Craig J.; Campos, Luis M.; Tirrell, Matthew V. “De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly”, NANOLETTERS, 2011 Sep 14;11(9):3946-50. Epub 2011 Aug 3.
  42. Lo Conte, M.; Robb, Maxwell J.; Hed, Yvonne; Marra, Alberto; Malkoch, Michael; Hawker, Craig J.; Dondoni, Alessandro, “Exhaustive Glycosylation, PEGylation, and Glutathionylation of a [G4]-ene(48) Dendrimer via Photoinduced Thiol-ene Coupling”, J. Polym. Sci., Polym. Chem.; 2011, 49, 4468-4475.
  43. Zhang, S.; Li, Z.; Samarajeewa, S.; Sun, G.; Yang, C.; Wooley, K. L. “Orthogonally Dual-clickable Janus Nanoparticles Templated Against Functional Nanoscopic Substrates”, J. Am. Chem. Soc., 2011 July 27; 133(29), 11046-11049, NIHMSID:309962.
  44. Lee, N. S.; Sun, G.; Lin, L. Y.; Neumann, W. L.; Freskos, J. N.; Karwa, A.; Shieh, J. J.; Dorshow, R. B.; Wooley, K. L. “Tunable Dual-emitting Shell-crosslinked Nano-objects as Single-component Ratiometric pH-sensing Materials”, J. Mater. Chem., 2011, 21(37), 14193-14202, DOI: 10.1039/C1JM11854D. Epub June 27
  45. Sun, G.; Cui, H.; Yun Lin, L.; Lee, N.S.; Yang, C.; Neumann, W.L.; Freskos, J.N.; Shieh, J.J.; Dorshow, R.B.; Wooley, K.L. "Multicompartment polymer nanostructures with ratiometric dual-emission pH-sensitivity", 2011, 133(22):8534-8543. PMID: 21574617.
  46. Amir, R.J.; Albertazzi, L.; Willis, J.; Khan, A.; Kang, T.; Hawker, C.J. "Multi-functional Trackable Dendritic Scaffolds and Delivery Agents", Angew. Chem.,2011 Apr 4;50(15):3425-9. DOI: 10.1002/anie.201007427. Epub 2011 Mar 9
  47. Pressly, E.D.; Amir, R.J.; Hawker, C.J. “Rapid Synthesis of Block and Cyclic Copolymers via Click Chemistry in the Presence of Copper Nanoparticles”, J. Polym. Sci., Polym. Chem.; 2011, Feb.; 49, 814-819.
  48. Shokeen, M.; Pressly, E. D.;  Hagooly, A.; Zheleznyak, A.; Ramos, N.; Fiamengo, A.L.; Welch, M.J.; Hawker, C. J.; Anderson, C. J. “Evaluation of multivalent, functional polymeric nanoparticles for imaging applications”, ACS Nano, available online at DOI: 10.1021/nn102278w.

Abstracts

  1. Harring, S.D., "Natriuretic Peptide Receptor-C is Upregulated in Diseased Carotid Neointima", 2011 National Predoctoral Clinical Research Training Program Meeting, St. Louis, MO, May 12, 2011.
  2. Wooley, K.L., “Tailoring of nanoscopic devices through chemistry”, American Association for Cancer Research Symposium: Nano in Cancer: Linking chemistry, biology, and clinical applications in vivo, Miami, FL, January 13, 2011.
  3. Wooley, K.L., “Sophisticated Plastics: Diverse opportunities – from materials to medicine – for well-defined polymer chemistry”, Hope College, Department of Chemistry, Holland, MI, December 3, 2010.
  4. Wooley, K.L., “Sophisticated Plastics: Diverse opportunities – from materials to medicine – for well-defined polymer chemistry”, Trinity University, Department of Chemistry, San Antonio, TX, November 11, 2010.
  5. Wooley, K.L., “Complex macromolecular and nanoscale structures by combinations of living radical and ring opening polymerizations”, 2010 Aldrich Symposium in Materials Science, University of Michigan, Ann Arbor, MI, November 8, 2010.

Patents

  1. Lee, B. F.; Lundberg, P.; van den Berg, S.; Pressly, E. P.; Hawker, C. J.; Lynd, N. A.; A reactive, hydrolytically-degradable unsaturated polyether: Poly[(ethylene oxide)-co-(methylene ethylene oxide)] 2012.
  2. Guo, K., Achilefu, S., Berezin, MY. Dating Bloodstains and biological fluids with fluorescence lifetime techniques. Filed by Washington University, Nov 30, 2011.

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